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Philanthropy For Basic Science:

Stem Cells

A Purkinje neuron in the cerebellum of a mouse. After a bone marrow transplant, two donor-derived cells were found in the brain of the recipient mouse.

James Weimann from Weimann JM, Johansson CB, Trejo A, & Blau HM, (2003). Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant. Nature Cell Biology 5, 959-966.

STEM CELL RESEARCH offers promise as a source of possible treatments for many diseases of aging, especially degenerative conditions. Such hopes are inspired by stem cells’ unique abilities: Under certain conditions, they can migrate to areas of damage, differentiate into cells of various types, and secrete trophic factors, chemical signals that help regulate cell life and death. In animal studies, transplantation of neural progenitor cells, which are partially differentiated cells, appears to have been effective in replacing lost neurons and restoring lost brain function.

"Regardless of the source of stem cells, there are problems that must be solved to turn them into agents for healing damage in tissues."

- Stuart A. Lipton

So far, most public discussion of this field has focused on political and ethical questions concerning use of embryonic stem cells in research. But one of the most exciting discoveries of the last decade has concerned adult stem cells – specifically the evidence that they can proliferate in the central nervous systems of vertebrates. Despite such hopeful findings, major challenges remain at every step of the long path that someday may lead to safe and useful treatments for humans. In its first five years, The Ellison Medical Foundation supported research that made significant contributions to meeting those challenges.


Articles related to Stem Cells

  • Altering Cell Fate
    Twenty years ago, in a paper in Science, Helen Blau reported that when various types of cells were fused with muscle cells, they could start expressing muscle genes. That finding challenged a widely held view that a terminally differentiated cell — a muscle cell, a blood cell — could never reach back and activate the untapped genetic potential of its embryonic days. In other words: Once a skin cell always a skin cell. Not necessarily, said Dr. Blau.


  • Related Projects

    Yasunori Hayashi, MD, PhD
    Yasunori Hayashi, MD, PhD
    Massachusetts Institute of Technology

    New Scholar in Aging 2001

    Role of Neural Progenitors in Adult Hippocampal- and Olfactory Bulb-Dependent Learning and Memory
    Helen M. Blau, PhD
    Helen M. Blau, PhD
    Stanford University School of Medicine

    Senior Scholar in Aging 2001

    Bone Marrow to Brain: Searching for Markers of Bone Marrow Stem Cells with Neurogenic Potential
    Stuart Lipton, MD, PhD
    Stuart Lipton, MD, PhD
    The Burnham Institute

    Senior Scholar in Aging 2001

    Use of Embryonic Stem Cells to Regenerate Neurons via the Transcription Factor hMEF2C
    Stephen Lyle, MD, PhD
    Stephen Lyle, MD, PhD
    Beth Israel Deaconess Medical Center, Harvard Medical School

    New Scholar in Aging 2002

    Molecular and Cell Biology of Adult Epithelial Stem Cells