The Ellison Medical Foundation Colloquium on the Biology of Aging

The Ellison Medical Foundation Colloquium on the Biology of Aging will be held Tuesday, August 9 through Thursday, August 11, 2011 at the Marine Biological Laboratory, Woods Hole, MA. Ellison Medical Foundation Senior Scholars and New Scholars from 2007, now in the final year of their awards, will be presenting their research at the colloquium. These Colloquium presentations are open to the public. Directions to the MBL and travel information are available at




The Ellison Medical Foundation
Tuesday, August 9 – Thursday, August 11, 2011
Marine Biological Laboratory
Lillie Auditorium



Tuesday, August 9, 2011

9:00 – 9:10 Introductions

9:10 – 9:45 Utz Herbig, Ph.D.
Telomere Dysfunction-Induced Senescence in Aging and Cancer

9:45 – 10:20 Emmanuel Skordalakes Ph.D.
Wistar Institute
Telomerase Structure Function

10:20 – 10:50 Break

10:50 – 11:25 Jan van Deursen, Ph.D.
Mayo Clinic College of Medicine
Inhibition of APC/CCdc20 by BubR1 regulates health- and life span

11:25 – 12:00 Avram Hershko, M.D., Ph.D.
Marine Biological Laboratory
Regulation of the APC/C ubiquitin ligase in the cell cycle: possible implications in aging

12:00 – 1:15 Lunch

1:15 – 1:50 Marion Schmidt, Ph.D.
Albert Einstein College of Medicine
Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae

1:50 – 2:25 Stephen Young, M.D.
University of California at Los Angeles
Fresh Insights into Nuclear Lamins and Laminopathies from Genetically Modified Mice

2:25 – 3:00 John Sedivy, Ph.D.
Brown University
The involvement of the c-Myc proto-oncogene in aging

Wednesday, August 10, 2011

9:00 – 9:35 Wei Gu, Ph.D.
Columbia University
p53 acetylation in tumor suppression and aging

9:35 – 10:10 Andrew Wurmser, Ph.D.
University of California at Berkeley
Glioma Cells Contribute to the Formation of Tumor Blood Capillaries

10:10– 10:40 Break

10:40 – 11:15 Rochelle Buffenstein, Ph.D.
University of Texas Health Science Center, San Antonio
Cancer Resistance And Genomic Stability In The Extraordinarily Long-Lived Naked Mole-Rat

11:15– 11:50 Alex Brodsky, Ph.D.
Brown University
Mechanisms from Genomics during Drosophila Aging

11:50 – 12:25 Anthony De Tomaso, Ph.D.
University of California at Santa Barbara
Aging and Regeneration in the Basal Chordate Botryllus schlosseri

12:30 – 1:45 Lunch

1:45 – 2:20 Sean Morrison, M.D.
University of Michigan
Maintenance of neurological function and adult stem cells by Bmi-1

2:20 – 2:55 Ronald Davis, Ph.D.
Scripps Research Institute
Age-dependent memory impairments analyzed by functional cellular imaging

2:55 – 3:30 Benjamin Eaton, Ph.D.
University of Texas Health Science Center, San Antonio
Increased presynaptic function by dietary restriction improves motor performance in a motor disease model

Thursday, August 11, 2011

9:00 – 9:35 Wulf Palinski, M.D.
University of California at San Diego
Targeting age-related diseases and aging mechanisms by interfering with maternal immunity and in utero programming

9:35-10:10 David Harrison, Ph.D.
The Jackson Laboratory
Testing the Hypothesis that Regulation of Female Reproductive Senescence is Cell Autonomous

10:10 – 10:40 Break

10:40 – 11:15 C. Ronald Kahn, M.D.
Joslin Diabetes Center, Harvard Medical School
Role of Adipose Tissue and miRNAs in Cell Non-Autonomous Regulation of Longevity and Stress Resistance Across an Evolutionary Spectrum

11:15 – 11:50 Adam Antebi, Ph.D.
Baylor College of Medicine
Nuclear hormone receptor control of the life plan and life span

11:50– 12:25 Heidi Tissenbaum, Ph.D. / A. J. Marian Walhout, Ph.D.
University of Massachusetts Medical School
Dissecting C. elegans insulins using a systems approach

12:30 – 1:45 Lunch

1:45 – 2:20 James Collins, Ph.D.
Boston University
A Network Biology Approach to Aging: Integrating Synthetic Biology and Systems Biology

2:20 – 2:55 Anthony Sauve, Ph.D.
Weill Medical College of Cornell University
Nicotinamide riboside is an endogenous neuroprotective agent that protects against mitochondrial dysfunction and genotoxic stress

2:55 – 3:30 David Sinclair, Ph.D.
Harvard Medical School
Insights into the importance of mitochondrial function in aging



4th Annual Joshua Lederberg Lecture
8:00 pm Lillie Auditorium
Introduction by
Goerge Martin, M.D.
Gerald Weissmann, M.D.
New York University School of Medicine
"“The Biochemistry of Inflammation: from Microciona to the Microbiome”"