The Ellison Medical Foundation Colloquium on the Biology of Aging

The Ellison Medical Foundation
COLLOQUIUM ON THE BIOLOGY OF AGING
Wednesday, August 11 – Friday, August 13, 2010
Marine Biological Laboratory
Lillie Auditorium

AGENDA

Wednesday, August 11, 2010

8:00 – 8:15 Introductions

8:15 – 8:40
Jan Vijg, Ph.D.
Albert Einstein College of Medicine
“Genome instability, aging and disease.”

8:40 – 9:05
Ravi Ranjan, Ph.D.
The University of Texas Health Science Center at San Antonio
“Secret of long-lived Methuselah revealed.”

9:05 – 9:30
Roger McCarter, Ph.D./Gerald McClearn, Ph.D.
Pennsylvania State University
Mechanisms of Longevity-Influencing Quantitative Trait Loci

9:30 – 9:55
Hong Zhang, Ph.D.
University of Massachusetts
Genetic Analysis of Senescence in Mammalian Aging

9:55 – 10:20 Break

10:20 – 10:45
Hui Sun, Ph.D.
University of California, Los Angeles
The Double-edged Sword of a Human Polymorphism Associated with a Major Aging Disease

10:45 – 11:10
Kenneth Paigen, Ph.D.
The Jackson Laboratory
“A. SA b-gal is not a marker of aging in mice. B. The control of genetic recombination in mice and humans

11:10 – 11:35
Andrei Seluanov, Ph.D.
University of Rochester
"Anticancer mechanisms in long lived rodents"

11:35 – 12:00
Tong Li, Ph.D.
The Johns Hopkins University
The Role of gamma-secretase as a Tumor Suppressor

12:00 – 1:00 Lunch

1:00 – 1:25
Gerard Evan, Ph.D.
University of California at San Francisco
"Balancing aging and tumor suppression"

1:25 – 1:50
Frank Slack, Ph.D.
Yale University
Control of life span by developmental timing microRNAs

1:50 – 2:15
David Chan, M.D., Ph.D.
California Institute of Technology
"Mitochondrial dynamics and mtDNA stability."

2:15 – 2:40
Tina Iverson, Ph.D.
Vanderbilt University Medical Center
The molecular contribution of mitochondrial complex II to the ageing process

2:40 – 3:05
Bruno Conti, Ph.D.
The Scripps Research Institute
Reduction of core body temperature prolongs life span of mice fed ad libitum - A transgenic model of calorie restriction?

3:05 – 3:30
Anne Hart, Ph.D.
Brown University
"Stress and longevity in C. elegans".

Thursday, August 12, 2010

8:00 – 8:25
Mitch McVey, Ph.D.
Tufts University
"Error-prone repair of DNA double-strand breaks and aging in Drosophila."

8:25 – 8:50
Kevin Mills, Ph.D.
The Jackson Laboratory
DNA Damage and Aging: Dissecting the Genetic Basis of Aging as a Complex Trait

8:50– 9:15
Sandra Wolin, M.D., Ph.D.
Yale University
"RNA Surveillance Pathways and Potential Links to Aging"

9:15 – 9:40
Malcolm Leissring, Ph.D.
Mayo Clinic Jacksonville
Insulin-degrading enzyme: an old enzyme with new links to Alzheimer’s, diabetes, and regulation of life span

9:40– 10:05
Adam Gazzaley, Ph.D.
University of California at San Francisco
Alterations in Neural Networks Underlying Cognitive Aging

10:05 – 10:35 Break

10:35 – 11:00
Michael Riehle, Ph.D.
The University of Arizona
“The elderly mosquito: Insulin’s role in aging, reproduction, and disease transmission”

11:00 – 11:25
Cheryl Conover, Ph.D.
Mayo Clinic and Foundation
A novel mouse model of diminished IGF signaling and extended lifespan

11:25 – 11:50
Bruce Spiegelman, Ph.D.
Dana-Farber Cancer Institute
Regulation of ROS Metabolism via the PGC-1 Coactivators

11:50 – 12:15
Marni Falk, Ph.D.
The Children’s Hospital of Philadelphia
Impact of free radical production on aging in C. elegans mitochondrial complex I subunit mutants

12:15 – 1:15 Lunch

1:15 – 1:40
David Marcinek, Ph.D.
University of Washington
"Mitochondrial adaptation to oxidative stress in aging and disease"

1:40 – 2:05
Richard Freiman, Ph.D.
Brown University
“A mouse model of premature reproductive aging”

2:05 – 2:30
Benoit Giasson, Ph.D.
University of Pennsylvania
The role of Lrrk2 mutations and aging in causing Parkinson's disease and related disorders

2:30 – 2:55
Toren Finkel, M.D., Ph.D.
NIH, National Heart, Lung and Blood Institute
The mammalian aging regulator klotho is an endogenous circulating Wnt antagonist

2:55 – 3:20
William Ogle, Ph.D.
University of Florida
Hormonal Control of Plasticity and Neurogenesis: Understanding the Molecular Pathways and Gene Dynamics Involved in Age related Memory Decline

Friday, August 13, 2010

8:00 – 8:25
Dylan Taatjes, Ph.D.
University of Colorado
"Molecular mechanisms that control p53 transcriptional activity and premature aging"

8:25– 8:50
Patricia Opresko, Ph.D.
University of Pittsburgh
Molecular Mechanisms of Telomeric DNA Instability Associated with the Human Progeroid Werner Syndrome

8:50 – 9:15
Mel Feany, M.D., Ph.D.
Brigham and Women’s Hospital
Genetic Basis of Age-Dependence in Neurodegenerative Diseases

9:15 – 9:40
Inder Verma, Ph.D.
The Salk Institute for Biological Studies
Novel Gene Delivery Methods in the Brain

9:40 – 10:05
Anshu Agrawal, Ph.D.
University of California at Irvine
'Impact of aging on human dendritic cell function'.

10:05 – 10:35 Break

10:35 – 11:00
Chris Schaffer, Ph.D.
Cornell University
Blood, Brains, and Lasers: Imaging microvascular disease in the brain of rodent models

11:00 – 11:25
Joseph McCarty, Ph.D.
U.T. M.D. Anderson Cancer Center
The Neurovascular Unit and Age-Related Neurodegeneration

11:25 – 11:50
Alexander Hoffmann, Ph.D.
University of California, San Diego
"NFkB in aging and senescence"

11:50 – 12:15
Jenny Hsieh, Ph.D.
University of Texas Southwestern Medical Center at Dallas
"Epigenetic control of adult hippocampal neurogenesis and age- related cognitive decline"

12:15 – 1:15 Lunch

1:15 – 1:40
Margaret Goodell, Ph.D.
Baylor College of Medicine
Mechanisms of Aging in Hematopoietic Stem Cells

1:40 – 2:05
Mark Davis, Ph.D.
Stanford University
"Analyzing influenza vaccine responses in older versus younger individuals."

2:05 – 2:30
Hidde Ploegh, Ph.D.
Whitehead Institute for Biomedical Research
Glycoprotein quality control in the immune system and agein

2:30 – 2:55
E. John Wherry, Ph.D.
The Wistar Institute
Cell-Extrinsic Regulation of Age-Related Deficits in Immune Responses to Infections