The Werner syndrome is a human genetic disorder associated with premature onset of symptoms resembling extreme aging. The disease is caused by a mutation in a helicase, but the specific cellular processes that are impaired by the absence of the helicase and the relationship of this impairment to the problems associated with normal aging are...
Senior and New Scholars Awards for Yale University School of Medicine
Dr. Sherman M. Weissman
Yale University School of Medicine
1999 senior Scholar Award in aging
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Dr. Ya Ha
Yale University School of Medicine
2002 new Scholar Award in aging
Human gamma-secretase is a large membrane protein complex catalyzing a novel reaction of intramembrane proteolysis. This activity is important in a number of cellular signaling pathways. There are three known gamma-secretase components, presenilin, nicastrin and beta-catenin. Mutations in presenilin cause familial and early-onset Alzheimer's... |
Dr. Stewart Frankel
Yale University School of Medicine
1999 new Scholar Award in aging
Aging is often depicted as an inevitable grinding down of the bodily machine, but there is much evidence to suggest it is a biological process under some genetic control. In order to better understand this process, we are attempting to speed up and slow down aging experimentally. This is being done by testing a series of mutations for an effect... |
Dr. David G. Wells
Yale University School of Medicine
2001 new Scholar Award in aging
The formation and maintenance of memories is one of the brain's most
intriguing functions. The human brain has the remarkable ability to store and
retrieve past experiences for years and in some instances decades. Changes in
memory occur with age and there is increasing evidence that there is a
considerable difference between the nature of...
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Dr. Jorge Galan
Yale University School of Medicine
2004 senior Scholar Award in gid
Campylobacter jejuni is one of the most common causes of bacterial diarrhea worldwide. Although these bacteria were not recognized as human enteric pathogens until the 1970’s, they are now recognized as the most common bacterial cause of acute infectious diarrhea in humans in the U.S. and Europe. Although there is... |
Dr. Peter Cresswell
Yale University School of Medicine
2001 senior Scholar Award in gid
It has been known for decades that a natural resistance mechanism for viral infections involves the production of interferons by infected cells. This family of antiviral molecules acts upon other cells to make them resistant to viral infection. Interferons induce the expression of a large number of molecules in the responding cells, but only a... |
Dr. Richard A. Flavell
Yale University School of Medicine
2003 senior Scholar Award in gid
All multi-cellular organisms live in an environment populated by infectious agents. In order to resist these infections, organisms from the simplest creatures such as flies, all the way up to humans have evolved special detectors of these infections. Upon the detection of these infections, defense systems are activated to cure the infection....
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Dr. Ruslan Medzhitov
Yale University School of Medicine
2004 senior Scholar Award in gid
Our bodies are equipped with an immune system to help protect us from infectious pathogens, such as bacteria and viruses. There are many different types of pathogens that can infect the host and, accordingly, there are many different ways in which the immune system can handle these pathogens. Recognition of infection generally leads to... |
Non-Scholar Awards for Yale University School of Medicine
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2003 Conferences and Workshops Scholar Award in Aging
The Ellison Medical Foundation awarded $10,000 to sponsor the ìModulation of the Innate and Acquired Immunity by Microbial Pathogensî section of the Gordon Research Conference on Molecular Mechanisms of Microbial Adhesion to be held July 27-August 1, 2003 in Newport, Rhode Island. For further information, see:
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Funded Institutions
The Ellison Medical Foundation fosters research by means of grants-in-aid on behalf of investigators to universities and laboratories within the United States. Institutions receiving awards must be tax-exempt 501(c)(3) organizations or U.S. colleges or universities.
The Ellison Medical Foundation