An understanding of the genetic factors that influence aging could lead to the identification of potential therapeutic targets to attenuate the suffering caused by debilitating health problems. Aging is conserved across species and single mutations within orthologous genes in nematodes, flies, and mice regulate longevity and age-related phenotypes...
Senior and New Scholars Awards for University of Rochester
Dr. Andrew Samuelson
University of Rochester
2010 new Scholar Award in aging
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Dr. Vera Gorbunova
University of Rochester
2009 senior Scholar Award in aging
The naked mole-rat is the longest living rodent with a maximum lifespan exceeding 28 years. In addition to its longevity, the naked mole-rat has extraordinary resistance to cancer as tumors have never been observed in these rodents. The mechanism for cancer resistance in the naked mole-rat is unknown. The goal of our research is to understand the...
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Dr. Andrei Seluanov
University of Rochester
2006 new Scholar Award in aging
Eastern grey squirrel is one of the longest-lived rodents. Its maximum documented lifespan is 23 years, which is almost 10 times longer than that of a mouse. Since squirrel is related to classical short-lived laboratory rodents such as mouse and rat, squirrel is an ideal model organism to identify factors that determine longevity.
Aging... |
Dr. Vera Gorbunova
University of Rochester
2003 new Scholar Award in aging
Aging cells and tissues accumulate point mutations and genomic rearrangements, consistent with a failing ability to defend their genomes against DNA damage. Rearrangements result primarily from errors in repair of double-strand breaks (DSBs), which arise commonly by breakage of replication forks, as a result of damage due to ionizing radiation... |
Dr. Heinrich Jasper
University of Rochester
2008 senior Scholar Award in aging
Regeneration is a critical biological process that allows preserving tissue function in multi-cellular organisms. Tissue-specific stem cells are central to this process, as they maintain the ability to divide and self-renew throughout adulthood, giving birth to a variety of specialized cell types that can replace damaged cells. The regenerative... |
Funded Institutions
The Ellison Medical Foundation fosters research by means of grants-in-aid on behalf of investigators to universities and laboratories within the United States. Institutions receiving awards must be tax-exempt 501(c)(3) organizations or U.S. colleges or universities.
The Ellison Medical Foundation