Caloric restriction (CR) is the most robust and reproducible way to delay or prevent age-related degeneration and disease in mammals. Although the mechanism accounting for these benefits remains poorly understood, a growing body of evidence implicates the sirtuin enzymes, a conserved family of proteins that use nicotinamide adenine dinucleotide (...

As life spans increase through improvements in medicine and public health, the prevalence of devastating nerve degeneration diseases will inexorably increase to become one of the most severe obstacles to living longer, more fulfilling lives. We are in urgent need of new concepts and approaches to combat several lethal nerve degeneration disorders...

Parkinsonís disease (PD) is the most common movement disorder affecting over one million people in North America alone. It is characterized clinically by resting tremor, slowness of movement, postural instability, and muscle rigidity with these disabilities largely attributed to the extensive loss of specific populations of neurons in the brain...