Cancers arise through the gradual acquisition of mutations in susceptible cells in the body - mutations that wreck the normal mechanisms that restrain cell growth, proliferation, survival movement and invasion and maintain normal architecture and dynamics of our tissue. There is an enormous number of cells in the human body with the...

During the last decade, remarkable discoveries in the small roundworm C. elegans have shown that aging is regulated hormonally by a regulatory system similar to that of the human insulin and IGF-1 (insulin-like growth factor) endocrine systems. This same endocrine system governs the aging process in fruit flies, and, recent studies show...

Fungal infections have increased dramatically in the past decade not only in developed countries—in large part due to advances in chemotherapy and organ transplantation—but also in the developing world, as a consequence of the progressive AIDS pandemic. Surprisingly, we know relatively little about how fungal infections are...