Genetic studies of human progeric syndromes have enhanced our understanding the molecular mechanisms of the aging process. Werner Syndrome (WS) is the segmental progeria considered to be most similar to natural senescence. WS fibroblasts display premature replicative senescence in culture and increased rates of telomere shortening. Telomeres...

Interlaced among the billions of neural cells in the human brain is an elaborate web of arteries, veins, and capillaries. Neural cells and vascular cells form a functionally integrated network that is collectively termed the neurovascular unit. The neurovascular unit regulates important physiological functions, and is linked to the onset and...