Aging of the Musculoskeletal System

2012 senior Scholar Award in aging

Sarcopenia, the atrophy and deterioration of skeletal muscle that leads to weakness and fatigue, is a major and debilitating consequence of aging. Moreover, because sarcopenia reduces physical activity and thereby compromises health by contributing to a wide range of complications in multiple... >> MORE

2012 senior Scholar Award in aging

One of the most prominent hallmarks of aging is a dramatic and often devastating decline in motor skills. Typically, a decline in motor coordination leads to problems in walking, including the ability to maintain a uniform gait and balance. Falls due to a loss of balance and motor coordination... >> MORE

2012 senior Scholar Award in aging

We are investigating the regeneration of normal, diseased and aged skeletal muscle with a focus on the mechanisms regulating muscle stem cell quiescence, self-renewal and terminal differentiation. The quiescent skeletal muscle stem cell resides in an asymmetric niche, sandwiched between the... >> MORE

2011 senior Scholar Award in aging

Human aging incorporates multiple changes throughout the body such as slower metabolism and loss of muscle. Aging is also associated with a reduced aerobic capacity as a result of reduced lung function, poorer blood circulation, decreased cardiac output, and limited exercise capacity. These age-... >> MORE

2011 senior Scholar Award in aging

The overall purpose of the work in our laboratory is to demonstrate that there is a hormonal regulation of organismal aging. This work is based on the observed effect of the bone-derived hormone osteocalcin in favoring glucose homeostasis, energy expenditure and male fertility. These three... >> MORE

2011 senior Scholar Award in aging

The overall goal of this project will be to test our hypothesis that stimulating anabolic pathways in skeletal muscle may lead to extension of life span. Specifically, we will examine the effect of blocking the myostatin signaling pathway on longevity in mice. We discovered myostatin as a... >> MORE

2011 senior Scholar Award in aging

Muscle fatigue is one of the most fundamental physiological processes. Fatigue of skeletal muscle determines the outer limits of physical activity and explains, for example, why an elite athlete who can run 100 meters in under 10 seconds cannot run 1,000 meters in 100 seconds. Severe muscle... >> MORE

2011 senior Scholar Award in aging

With “normal” aging, many individuals experience a profound loss of muscle strength. The changes in muscle structure that lead to muscle weakness are the basis of the degenerative disease known as sarcopenia, which has become a major affliction for millions of people worldwide. While many... >> MORE

2010 senior Scholar Award in aging
Loss of muscle mass and degeneration of the fibers that make up skeletal muscle, a condition called sarcopenia, are major hallmarks of aging. Muscle loss and degeneration contribute to many other ill-effects of aging including frequent bone fractures and insulin resistance, a pre-diabetic condition... >> MORE
2013 new Scholar Award in aging

The progressive loss of skeletal muscle function and mass (sarcopenia) is a serious feature of aging and a key component of the geriatric syndrome of frailty. Epidemiological surveys in humans indicate that muscle aging influences the progression of several age-related diseases in other tissues... >> MORE

2011 new Scholar Award in aging

Aging is characterized by a progressive decline of tissue function associated with loss of regenerative potential. With age stem cell compartments are progressively less efficient in maintaining tissue homeostasis, and tissues undergo atrophy. These changes have been associated with critical... >> MORE

2009 new Scholar Award in aging
Sarcopenia, or degenerative loss of skeletal muscle mass and function, is an increasing health concern in the United States, causing elderly people to sacrifice their independence and rely on institutionalized care due to immobility and loss of strength. Although reductions in both the size and... >> MORE
2009 new Scholar Award in aging

Organismal aging is characterized by a decline in regenerative capacity leading to reduced physiological function. Skeletal muscle has an impaired regenerative response during aging, largely due to defects in the muscle stem cells (the satellite cells), which are almost solely responsible for... >> MORE

2008 new Scholar Award in aging
Over 20 million people in the United States suffer from osteoarthritis, a degenerative joint disease in articular cartilage with increased incidence observed with age. This disease often reduces an individualís ability to function as a result of inflammation, pain, and decreased mobility.... >> MORE
2001 new Scholar Award in aging
Sarcopenia, progressive loss of muscle mass and quality, is the principle component of the profound changes in body composition that occur with aging, and it is a large factor in loss of strength, deficits in gait, and reduced metabolic rate in the elderly. We will apply two novel methods to... >> MORE