Loss of muscle mass and degeneration of the fibers that make up skeletal muscle, a condition called sarcopenia, are major hallmarks of aging. Muscle loss and degeneration contribute to many other ill-effects of aging including frequent bone fractures and insulin resistance, a pre-diabetic condition... >> MORE

Sarcopenia, or degenerative loss of skeletal muscle mass and function, is an increasing health concern in the United States, causing elderly people to sacrifice their independence and rely on institutionalized care due to immobility and loss of strength. Although reductions in both the size and... >> MORE

Organismal aging is characterized by a decline in regenerative capacity leading to reduced physiological function. Skeletal muscle has an impaired regenerative response during aging, largely due to defects in the muscle stem cells (the satellite cells), which are almost solely responsible for...

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