Aging of the Visual System

2011 senior Scholar Award in aging

“You are only as old as your plumbing.” With that characteristically pithy remark, Sir William Osler summarized his view of the relationship between aging and diseases that affect the vascular system, the body’s plumbing. One hundred years later, vascular diseases remain a leading cause of death... >> MORE

2000 senior Scholar Award in aging
Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly population. However, little is known about the etiology and molecular pathophysiology of AMD. AMD is characterized clinically by mottling of the retinal pigment epithelium (RPE) at the posterior pole of the... >> MORE
2006 new Scholar Award in aging
The large increase in human life expectancy during the last century has been accompanied by a significant increase in the incidence of aging diseases such as age-related macular degeneration (AMD). AMD is now the leading cause of irreversible blindness in the elderly in Western societies. Recent... >> MORE
2005 new Scholar Award in aging
We have uncovered the complement factor H (CFH) being a major gene for Caucasian patients with age-related macular degeneration (AMD). At present, little is known about differences in genetic risk factors contributing to AMD among various ethnic backgrounds. Are the specific clinical feature... >> MORE
2003 new Scholar Award in aging

Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in developed countries. Retinal pigment epithelial (RPE) degeneration initiates AMD. Oxidative stress has been suggested for RPE aging/degeneration. However, corneal epithelilal cells (CE) rarely suffer from... >> MORE