Aging of the Reproductive System

2007 senior Scholar Award in aging
Precursor cells that continuously regenerate are vital for health. In order to cure or postpone age-related functional deterioration and disease, it is necessary to identify which precursor cells regulate the rates of aging in various biological systems. Dr. Harrison and his associates are... >> MORE
2005 senior Scholar Award in aging

It is well known that advanced maternal age increases the risk of giving birth to children with Down syndrome, and a significant effort has been made to understand the molecular basis of this increased risk. What is less well known is that advanced paternal age is also associated with an... >> MORE

2012 new Scholar Award in aging

The Ghazi lab uses Caenorhabditis elegans as a model to understand the genetic mechanisms that influence how long animals live and how they age. We are particularly interested in the relationship between aging and reproduction, two fundamental aspects of our lives.

Traditionally... >> MORE

2009 new Scholar Award in aging
Loss of reproductive fitness is a hallmark of aging, conserved from yeast to humans. Not only does aging result in fewer progeny, it can also affect ìquality,î as progeny produced late in life may be inviable or otherwise less fit. Women over a certain age are at a higher risk for miscarriages or... >> MORE
2006 new Scholar Award in aging
Proper organ development and maintenance is often accomplished through multiple cell types within a tissue that express distinct gene products and collectively support common functions. For example, the mammalian testis is composed of male germ cells (the gametes) and supporting somatic cells that... >> MORE
2006 new Scholar Award in aging
My lab is interested in the link that exists between aging and reproduction. It has been observed that increased reproduction often leads to a decrease in lifespan and vice versa. One possible mechanism for this balance is the insulin/IGF-1 signaling cascade (ISC). It has been convincingly... >> MORE
2005 new Scholar Award in aging

Loss of tissue and organ function is a characteristic of organismal aging, and such changes have been attributed to decreases in stem cell function. Stem cells are the building blocks during development of organisms as varied as plants and humans. In addition, stem cells provide for the... >> MORE