Accelerated Aging

2010 senior Scholar Award in aging

Despite the importance of ageing studies, we are still lacking appropriate cell models that can mimic normal human ageing to study ageing-related human diseases. Very recently, striking similarities between physiological ageing and the premature-ageing disease Hutchinson-Gilford Progeria... >> MORE

2007 senior Scholar Award in aging
Progeroid syndromes are groups of diseases in which patients develop features of accelerated aging early in life. Two of the best-known progeroid syndromes are Hutchinson-Gilford progeroid syndrome (HGPS, ìProgeria of Childhoodî) and Werner syndrome (WS, ìProgeria of Adultsî). HGPS is a... >> MORE
2007 senior Scholar Award in aging
Hutchinson-Gilford progeria syndrome (HGPS) is a rare pediatric genetic disease associated with many features that resemble aging. This disease is caused by an abnormal version of prelamin A, the precursor to lamin A, which is a molecule that helps form the structural scaffolding for the cell... >> MORE
2004 senior Scholar Award in aging

It has been thought for over 100 years that an understanding of the cause of an early onset premature aging disease called Hutchinson-Gilford Progeria Syndrome (HGPS), would provide insights into normal human aging. Progeria is an extremely rare disease that was recently found to be caused by... >> MORE

1999 senior Scholar Award in aging

The Werner syndrome is a human genetic disorder associated with premature onset of symptoms resembling extreme aging. The disease is caused by a mutation in a helicase, but the specific cellular processes that are impaired by the absence of the helicase and the relationship of this impairment... >> MORE

2012 new Scholar Award in aging

Although aging is an immensely complicated process, one characteristic of aging is increased susceptibility to cancer, which can result from genetic instability. Our cells are exposed to DNA damaging agents daily, such as UV irradiation, and as we age the ability of our cells to repair these... >> MORE

2011 new Scholar Award in aging

Cellular senescence is a useful in vitro model for exploring molecular mechanisms underlying normal human aging. A popular hypothesis is that when the telomeres shorten to below a critical point, it acts as a mitotic clock dictating the permanent exit from the cell cycle. Besides... >> MORE

2011 new Scholar Award in aging

Most of the DNA in our cells exists as a stable double-stranded molecule that is packaged into a compact structure known as chromatin. This compact or 'closed' structure prevents the interaction of the DNA with specific factors. During certain normal cellular activities such as DNA replication,... >> MORE

2006 new Scholar Award in aging
Maintenance of the genome is critical for the survival and health of an organism. Genomic mutations and alterations promote cancer, and the incidence of cancer increases exponentially with age. My lab is investigating the mechanisms of genomic instability associated with aging and diseases... >> MORE
2004 new Scholar Award in aging

Accumulation of DNA damage and loss of telomere protection contribute significantly to the aging process. The Nbs1, Mre11 and Rad50 complex (NMR) plays an important role in DNA double strand break (DSB) repair and telomere maintenance. Two components of this complex, Nbs1 and Mre11, are mutated... >> MORE

2001 new Scholar Award in aging

Genetic studies of human progeric syndromes have enhanced our understanding the molecular mechanisms of the aging process. Werner Syndrome (WS) is the segmental progeria considered to be most similar to natural senescence. WS fibroblasts display premature replicative senescence in culture and... >> MORE

2000 new Scholar Award in aging

Throughout life, our DNA is constantly subject to damage from both environmental agents and endogenous reactive oxygen species. Due to incomplete repair of this damage, changes in DNA accumulate in each cell as time passes. Such changes (mutations) are known to have a role in the etiology of... >> MORE

2000 new Scholar Award in aging

Genome instability has long been proposed to be a major factor in the aging process. The contribution of genome instability to aging is underscored by the finding that several of the segmental progeroid syndromes, which are characterized by early onset of conditions normally associated with... >> MORE

1999 new Scholar Award in aging
Werner Syndrome (WS) is a rare human genetic disease with many features of premature aging. The patients usually appear normal during their teenage years. But later they prematurely develop several age-related diseases, including artherosclerosis, osteoporosis, diabetes, malignant neoplasm and... >> MORE
1998 new Scholar Award in aging

Werner syndrome (WS) is a rare genetic disorder associated with premature aging and increased risks for cancer. The gene underlining WS has been cloned and found to encode a member of the RecQ DNA helicase family. In addition to the drastic mutations found in WS patients, there are also... >> MORE