Aging of the Cardiovascular System

2011 senior Scholar Award in aging

Muscle fatigue is one of the most fundamental physiological processes. Fatigue of skeletal muscle determines the outer limits of physical activity and explains, for example, why an elite athlete who can run 100 meters in under 10 seconds cannot run 1,000 meters in 100 seconds. Severe muscle... >> MORE

2011 senior Scholar Award in aging

“You are only as old as your plumbing.” With that characteristically pithy remark, Sir William Osler summarized his view of the relationship between aging and diseases that affect the vascular system, the body’s plumbing. One hundred years later, vascular diseases remain a leading cause of death... >> MORE

2008 senior Scholar Award in aging
We intend to take advantage of the genetic model system of the fruit fly Drosophila and its simple heart to probe and investigate the mechanisms of organ-specific aging. Past studied have established that basic mechanisms of heart formation and establishment of regular heart contractions are... >> MORE
2006 senior Scholar Award in aging
The old heart is a stiff heart and thus is less easily able to fill with blood and empty with each heart beat. The emphasis of this project is on studies designed to determine the basis for this increased stiffness of the heart in aging. Fibroblasts are the most numerous cells in the heart and... >> MORE
2005 senior Scholar Award in aging
Time asymmetry (irreversibility), also referred to as the ìarrow of time,î is a fundamental property of systems that operate far from equilibrium. The emergence of such nonequilibrium dynamics-- essential for life--requires the expenditure of energy and leads to irreversible changes.

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2013 new Scholar Award in aging

The incidence of myocardial infarction (MI), also known as heart attack, significantly increases with age, and is the leading cause of morbidity and mortality among the population aged 65 years and older. The underlying pathology is typically loss of cardiomyocytes that leads to heart failure.... >> MORE

2010 new Scholar Award in aging
Ischemic disease of heart, brain, or limbs is almost a sine qua non of advanced age. Most people in the developed world eventually die from ischemic causes. Ischemic tissues can create new blood vessels (angiogenesis), in an attempt to recruit more oxygen and nutrients. That response, however,... >> MORE
2008 new Scholar Award in aging
Aging is associated with a decline in cardiac performance and an increase in the incidence of heart failure. Following a heart attack, there is immediate damage to a section of the heart muscle. Older patients after heart attacks are more likely to suffer heart failure or die, compared to young... >> MORE
2008 new Scholar Award in aging
Cardiovascular disease remains a leading cause of death in an aging population. Cardiac aging is predominantly characterized by hypertrophy and fibrosis, but the molecular mechanisms underlying cardiac aging are unknown. The aging heart is stiff, possesses less contractile power and is more... >> MORE
2007 new Scholar Award in aging
Aging is the single largest risk factor for cardiovascular diseases, which are the leading cause of death of individuals over the age of 65 years. Atherosclerosis is so common in older persons (at least one out of two persons over sixty five years of age has atherosclerosis) and it is thought that... >> MORE
2006 new Scholar Award in aging

Interlaced among the billions of neural cells in the human brain is an elaborate web of arteries, veins, and capillaries. Neural cells and vascular cells form a functionally integrated network that is collectively termed the neurovascular unit. The neurovascular unit regulates important... >> MORE

2006 new Scholar Award in aging
Adult neural stem cells are brain-specific somatic stem cells that localize to interfaces with the vasculature within proliferative clusters comprised of neuronal, glial, endothelial and smooth muscle cells. This concentration of newly-formed cells and vascular structures define the extracellular... >> MORE
2002 new Scholar Award in aging
The fruit fly Drosophila melanogaster has served as a valuable model-organism for the study of aging and was the first organism possessing a circulatory system to have its genome completely sequenced. Little is known, however, about... >> MORE
2000 new Scholar Award in aging
The incidence of ischemic heart disease increases with advancing age. Unfortunately, the physiologic response to cardiac myocardial ischemia, the angiogenic development of new blood vessels, is decreased in the elderly population as demonstrated by both clinical and experimental studies.

The... >> MORE