p53 genes link environmental stressors to adaptive cellular responses, affecting life span and cancer susceptibility. As a protein, p53 acts to regulate the expression of so-called target genes, analogous to an integration device, which responds to stimuli by operating switches that turn sets of... >> MORE
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2011 Senior Scholar Award in Aging |
2011 Senior Scholar Award in Aging Parkinson’s disease (PD) is a progressive neurodegenerative disorder that constitutes the major cause of neurological motor impairment in the elderly and as such places an extraordinary burden on the US health care system, at an estimated cost of $25 billion annually. The major risk factor for... >> MORE |
Dr. Eric Baehrecke
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2011 Senior Scholar Award in Aging The decline of cognitive function is one of the greatest health threats for the aged population. It has been widely accepted that mainly loss of synaptic connections, rather than loss of neurons, is responsible for age-associated cognitive impairment. However the molecular mechanisms underlying... >> MORE |
2011 Senior Scholar Award in Aging Our research into the relationship between body temperature and longevity was stimulated by two related observations in animal systems. It has been known for almost fifty years that dietary caloric restriction in many species (including primates) could extend life. In the course of those... >> MORE |
Dr. Craig Crews
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Dr. George Daley
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Dr. Pietro De Camilli
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Dr. James Eberwine
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2011 Senior Scholar Award in Aging Human aging incorporates multiple changes throughout the body such as slower metabolism and loss of muscle. Aging is also associated with a reduced aerobic capacity as a result of reduced lung function, poorer blood circulation, decreased cardiac output, and limited exercise capacity. These age-... >> MORE |
2011 Senior Scholar Award in Aging Proteins must achieve their correct three-dimensional folded structure in order to carry out their cellular functions. Failure to fold its proteins can be catastrophic for cells, since misfolded proteins can aggregate into toxic amyloid species. Aging is universally associated with a decline in... >> MORE |
2011 Senior Scholar Award in Aging The overall purpose of the work in our laboratory is to demonstrate that there is a hormonal regulation of organismal aging. This work is based on the observed effect of the bone-derived hormone osteocalcin in favoring glucose homeostasis, energy expenditure and male fertility. These three... >> MORE |
Dr. James Kirkland
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2011 Senior Scholar Award in Aging The overall goal of this project will be to test our hypothesis that stimulating anabolic pathways in skeletal muscle may lead to extension of life span. Specifically, we will examine the effect of blocking the myostatin signaling pathway on longevity in mice. We discovered myostatin as a... >> MORE |
Dr. Andrew Marks
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Dr. Richard Morimoto
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2011 Senior Scholar Award in Aging “You are only as old as your plumbing.” With that characteristically pithy remark, Sir William Osler summarized his view of the relationship between aging and diseases that affect the vascular system, the body’s plumbing. One hundred years later, vascular diseases remain a leading cause of death... >> MORE |
2011 Senior Scholar Award in Aging A major challenge in basic research on aging is to distinguish among various potential causative influences of age-related diseases. There have been many hypothesis put forward to explain the deterioration of tissue homeostasis and regenerative capacity during aging. Age-induced accumulation of... >> MORE |
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2011 Senior Scholar Award in Aging The p53 protein is a prominent tumor suppressor, often referred to as the “guardian of the genome”. p53 is stabilized and activated in response to a variety of stress signals and, in turn, activates specific target genes through its function as a conventional transcription factor that binds to... >> MORE |
2011 Senior Scholar Award in Aging With “normal” aging, many individuals experience a profound loss of muscle strength. The changes in muscle structure that lead to muscle weakness are the basis of the degenerative disease known as sarcopenia, which has become a major affliction for millions of people worldwide. While many... >> MORE |
Dr. David Sabatini
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2011 Senior Scholar Award in Aging The overall goal of our application is to initiate a novel series of studies that demonstrate a role for the hypothalamus in regulation of aging and age-related disease. Several studies suggest that hypothalamic mechanisms regulate aspects of aging in both invertebrates and vertebrates but their... >> MORE |
2011 Senior Scholar Award in Aging We are interested in determining the mechanisms underlying age-related declines in tissue homeostasis and repair. Following embryogenesis, most animals undergo a dramatic period of growth, during which the body, and all its component parts, increase in size and mass. On reaching adulthood, net... >> MORE |
Dr. Sally Temple
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2011 Senior Scholar Award in Aging Aging is a complex process that occurs at both cellular and organismal levels. As cells age, the ends of their chromosomes, so called telomeres, are gradually eroded. Eroded telomeres are recognized by cells as broken DNA ends, eliciting checkpoint responses and a senescence cellular state in... >> MORE |
The Ellison Medical Foundation