Hormones are well known to coordinate animal metabolism, reproduction, and homeostasis to maximize survival and reproductive success. Pioneering work in the small roundworm Caenorhabditis elegans has revealed that several hormones also impact animal longevity. Nuclear hormone receptors... >> MORE
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2007 Senior Scholar Award in Aging |
2007 Senior Scholar Award in Aging Remarkable progress in genomic research is leading to a complete map of the building blocks of biology. Knowledge of this map is, in turn, fueling the study of gene regulation, where proteins often regulate their own production, or that of other proteins, in a complex web of interactions. An... >> MORE |
2007 Senior Scholar Award in Aging Memory impairment is one of the common complaints of the elderly. Although significant progress has been made in recent years in understanding the basic biology of memory formation in animal models, the biological basis for memory impairment with aging remains obscure. We will use the fruit... >> MORE |
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2007 Senior Scholar Award in Aging The work leading up to the proposal for The Ellison Medical Foundation represents a novel paradigm for human aging and "premature aging" disorders in that it reverses the widely accepted notion that cell division creates two identical daughter cells. Cell division is the fundamental... >> MORE |
2007 Senior Scholar Award in Aging The continued replenishment of many tissues in the body, such as the skin, intestine and blood, depends on adult stem cells. When an adult stem cell divides, it produces one cell like itself and one cell that differentiates to perform a specialized function. While this pattern of division... >> MORE |
2007 Senior Scholar Award in Aging Precursor cells that continuously regenerate are vital for health. In order to cure or postpone age-related functional deterioration and disease, it is necessary to identify which precursor cells regulate the rates of aging in various biological systems. Dr. Harrison and his associates are... >> MORE |
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2007 Senior Scholar Award in Aging Aging is associated with a large increase in the incidence of cancer. One possible cause that has not yet been investigated is that age-related cancer may be due to abnormalities in the degradation of proteins that regulate cell division. Cell division is normally controlled by oscillations in... >> MORE |
2007 Senior Scholar Award in Aging While many factors contribute to longevity, studies over the last decade have revealed particularly important roles for the activity of the insulin and IGF-1 signaling systems. Indeed, these signaling systems have been shown to play a role in control of lifespan in organisms as diverse as worms,... >> MORE |
2007 Senior Scholar Award in Aging Aging is associated with reduced regeneration and impaired function in a variety of tissues including the brain. Neural stem cells and the formation of new neurons (neurogenesis) persist throughout life in the brain, but decline with age. These declines have been hypothesized to contribute to... >> MORE |
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2007 Senior Scholar Award in Aging Progeroid syndromes are groups of diseases in which patients develop features of accelerated aging early in life. Two of the best-known progeroid syndromes are Hutchinson-Gilford progeroid syndrome (HGPS, ìProgeria of Childhoodî) and Werner syndrome (WS, ìProgeria of Adultsî). HGPS is a... >> MORE |
2007 Senior Scholar Award in Aging Substantial epidemiological evidence indicates that conditions in utero program the susceptibility to age-related diseases, in particular atherosclerosis, the underlying cause of most heart attacks and strokes. However, little is known about maternal factors responsible for such... >> MORE |
2007 Senior Scholar Award in Aging Aging is characterized by a gradual functional decline of most organ systems. At the cellular level, virtually all somatic cells possess a limited proliferative lifespan after which they enter into a terminal growth arrest known as cellular senescence. Telomeres are specialized structures found at... >> MORE |
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2007 Senior Scholar Award in Aging For over 70 years it has been known that animals such as mice and monkeys have internal defense systems that fend off common diseases such as cancer, diabetes, heart disease and neurodegeneration. In the past five years researchers have discovered genes that underlie the CR response but this is... >> MORE |
2007 Senior Scholar Award in Aging Immunosenescence is believed to be an important component of old age and may be related to tumorigenesis and to susceptibility to virus infections. Very little is known about its mechanism, particularly in molecular terms. In the past five years natural killer cell (NK) and dendritic cell (DC)... >> MORE |
Dr. Marian WalhoutUniversity of Massachusetts Medical School
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2007 Senior Scholar Award in Aging Accurate segregation of chromosomes during mitosis is essential for maintenance of genomic integrity. Errors in this process cause an abnormal chromosome content, known as aneuploidy, which is a hallmark of most human cancers. To test whether aneuploidy is a cause or a consequence of the malignant... >> MORE |
2007 Senior Scholar Award in Aging Hutchinson-Gilford progeria syndrome (HGPS) is a rare pediatric genetic disease associated with many features that resemble aging. This disease is caused by an abnormal version of prelamin A, the precursor to lamin A, which is a molecule that helps form the structural scaffolding for the cell... >> MORE |
The Ellison Medical Foundation