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2002 New Scholar Award in Aging The overall goal of this study is to isolate mitochondrial DNA (mtDNA) mutations associated with aging, to analyze the accumulation of the mutations during aging and to determine the genetic and functional consequences of the age-dependent mtDNA mutations in mouse. In mammalian cells, over 90% of... >> MORE |
2002 New Scholar Award in Aging Chemical genetics relies on using small, cell-permeable molecules that interact with proteins and create a loss or a gain of function of proteins similarly to genetic mutations. The active compounds are obtained by the in vivo screening of libraries of chemicals for the desired cellular phenotype,... >> MORE |
2002 New Scholar Award in Aging A common feature of aging is the accumulation of abnormal or damaged proteins inside cells with a consequent negative effect in cell function. Any attempt to remove these abnormal proteins may help in the functional recovery of different organs affected in aged organisms. Damaged or abnormal... >> MORE |
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2002 New Scholar Award in Aging Human gamma-secretase is a large membrane protein complex catalyzing a novel reaction of intramembrane proteolysis. This activity is important in a number of cellular signaling pathways. There are three known gamma-secretase components, presenilin, nicastrin and beta-catenin. Mutations in... >> MORE |
2002 New Scholar Award in Aging Progressive loss of neurons in the brain is a hallmark of many neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. The only known risk factor for the majority of such patients is aging. Nonetheless, most people do not develop these disorders during aging, so other... >> MORE |
2002 New Scholar Award in Aging Alzheimer's disease (AD) is the most common form of age-related dementia and one of the most serious health problems in the U.S. Most cases of early-onset familial Alzheimer's disease (FAD) are caused by mutations in two related genes, known as presenilin 1 and 2 (PS1 and PS2). Deciphering the... >> MORE |
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2002 New Scholar Award in Aging The skin undergoes significant structural and functional changes with aging, secondary to both intrinsic and environmental factors. The epidermis and dermis become thinner, lose their normal rete pattern, exhibit decreased elasticity and show a decreased number of melanocytes. The hair becomes... >> MORE |
2002 New Scholar Award in Aging The fruit fly Drosophila melanogaster has served as a valuable model-organism for the study of
aging and was the first organism possessing a circulatory system to have its genome completely
sequenced. Little is known, however, about... >> MORE |
2002 New Scholar Award in Aging Our research focuses on the effects of genetic and environmental factors on brain function in
experimental mouse models of human neurological diseases. Routinely, we use a combination of
behavioral, neuroendocrine, and neurochemical... >> MORE |
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2002 New Scholar Award in Aging Dietary restriction (DR, also referred to as calorie restriction, food restriction, and energy restriction) is the best-studied method of retarding senescence and mortality in mammals ñ extending life span by as much as 50% in rodents. Understanding the molecular mechanism by which DR extends life... >> MORE |
The Ellison Medical Foundation